Abstract #3147

Evaluating brain oxygen metabolism and cognition in multiple sclerosis

Kathryn L West¹, Dinesh K Sivakolundu¹, Mark D Zuppichini¹, Gayathri B Maruthy¹, Darin T Okuda², Hanzhang Lu³, and Bart Rypma¹

¹Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, United States, ²Neurology, University of Texas Southwestern, Dallas, TX, United States, ³Radiology, Johns Hopkins University, Baltimore, MD, United States

We used phase contrast (PC) and T₂-Relaxation-Under-Spin-Tagging (TRUST) to evaluate whole brain cerebral metabolic rate of oxygen (CMRO₂) in MS patients and healthy controls. We compared CMRO₂ with cognitive performance and diffusion kurtosis imaging. CMRO₂correlates negatively with cognitive function in MS patients, suggesting a marker of ongoing disease activity leading to cognitive decline.

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