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Abstract #3141

In-vivo mapping of thalamic pathological mechanisms in pediatric patients with MS

Loredana Storelli1, Ermelinda De Meo1,2, Lucia Moiola2, Maria Pia Amato3, Angelo Ghezzi4, Pierangelo Veggiotti5,6, Ruggero Capra7, Maria A. Rocca1,2, and Massimo Filippi1,2

1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 3Department NEUROFARBA, Section Neurosciences, University of Florence, Florence, Italy, 4Multiple Sclerosis Center, Ospedale di Gallarate, Gallarate, Italy, 5Department of Child Neurology and Psychiatry, C. Mondino National Neurological Institute, Pavia, Italy, 6Brain and Behaviour Department, University of Pavia, Pavia, Italy, 7Multiple Sclerosis Center, Spedali Civili of Brescia, Brescia, Italy

Despite widely recognized in pediatric population with multiple sclerosis (MS), the pathogenesis of thalamic damage remains largely unknown. This study was performed to explore the microstructural abnormalities within this structure through the use of quantitative MRI metrics (diffusion tensor, T1/T2-weighted ratio) considering the two different thalamic interfaces (cerebrospinal fluid/thalamus and thalamus/white matter) as sites of two different pathogenic processes: the first one accounting for cerebrospinal fluid-mediated factor damage and the second one for diffuse neurodegenerative damage. The study demonstrated an heterogeneous pathogenesis for thalamic damage since the beginning of the disease.

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