Abstract #3118

Voxel Based Morphometry in Temporal Lobe Epilepsy: a pilot study using MT maps instead of conventional T1-weighted data

Fulvia Palesi¹, Paul Eugene Summers¹, Claudia A.M. Gandini Wheeler-Kingshott^2,3,4, Giancarlo Germani¹, Valeria Mariani⁵, Laura Tassi⁵, and Paolo Vitali¹

¹Neuroradiology Unit, Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Italy, ²Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ³Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁴Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Italy, ⁵”C.Munari” Epilepsy Surgery Centre, ASST Ospedale Metropolitano Niguarda, Milan, Italy

Temporal Lobe Epilepsy (TLE) is the most common form of focal epilepsy. Neuroimaging and neuropathological studies indicates that the structural network affected in TLE extends to both temporal and extra-temporal structures. In this work, quantitative 3DMT maps were used in a Voxel Based Morphometry(VBM) framework to assess atrophy in left and right TLE compared to controls. Our findings revealed that 3DMT maps, thankfully to their excellent grey-white matter contrast, can be successfully employed for VBM in epilepsy identifying temporal and extra-temporal grey and white matter alterations in patients. This study is a proof-of-principle to adopt 3DMT for voxel based analysis in TLE.

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