Preliminary Research of ischemic penumbra in human subacute stroke patients combinating use of amide proton transfer (APT) Chemical Exchange Saturation Transfer (CEST) and arterial spin-labeling (ASL) MRI

The purpose of this word was to explore the feasibility of amide proton transfer(APT) assisting arterial spin-labeling(ASL) and diffusion-weighted imaging(DWI) in identiflication and definition of ischemic penumbra in subacute stroke .Our results showed that APTWI deficits were always larger than or equal to DWI deficits and smaller than or equal to ASL-CBF deficits in subacute stroke. ATPWI deficits coincided with the resulting infarct area at follow-up endpoint. Final infarcts were smaller than CBF deficits and larger than or equal to subacute DWI deficits.APT can provide information complementary on cell metabolism to ASL and DWI in the definition of ischemic tissue.