Abstract #3100

3D-QALAS Sequence for Brain Volumetry and Cortical Thickness: Comparison with 3D MPRAGE and Scan-Rescan Repeatability

Shohei Fujita¹, Akifumi Hagiwara^1,2, Masaaki Hori¹, Fukunaga Issei¹, Christina Andica¹, Tomoko Maekawa^1,2, Ryusuke Irie^1,2, Koji Kamagata¹, Kanako K Kumamaru¹, Akihiko Wada¹, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, The University of Tokyo, Tokyo, Japan

Previous quantitative synthetic MRI of the brain has been solely performed in 2D. Here, we evaluated the feasibility of the recently developed 3D-QALASsequence for brain cortical thickness and volumetric analysis in healthy volunteers. 3D-QALAS and MPRAGE were performed twice and once, respectively, in the same session at 1.5 T. FreeSurfer and FIRST were used to measure cortical thickness and volume of subcortical structures, respectively. High agreement with MPRAGE and scan-rescan repeatability in both cortical thickness and subcortical structures were shown. 3D-QALAS could be reliably used for measuring cortical thickness and subcortical volumes in most brain regions.

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