We present the first large-scale evaluation of Wave-CAIPI susceptibility-weighted imaging (Wave-SWI) for clinical brain imaging. Wave-SWI was compared to conventional SWI in 107 patients undergoing 3T MRI for a range of indications in both inpatient and outpatient settings. Two neuroradiologists assessed the images in individual and head-to-head comparisons, and found no significant difference between the two sequences for detection of microhemorrhages, visualization of pathology and normal anatomy, and overall diagnostic quality, despite a nearly 5-fold decrease in acquisition time using Wave-SWI. Broader application of highly-accelerated 3D imaging may improve utilization of MRI resources while reducing motion artifacts and patient anxiety.
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