Hippocampal metabolite ratios can be used as clinical biomarkers to diagnose Alzheimer’s disease (AD), yet the metabolite ratios at a subfield level have been rarely reported, neither for its clinical diagnostic power. We aim to investigate the diagnostic power of metabolite ratios at a subfield level in AD with comparison to the whole level. A quantitative method of metabolite ratios was used, where 2D 1H-MRSI and 3D T1W volumetric MRI were co-registered. Statistical results show subfields have better diagnostic power than the whole hippocampus through metabolite ratios, and also prove the accuracy of the method for AD diagnosis.
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