Mild traumatic brain injury (mTBI) is difficult to diagnose and characterize. In this study, we applied simultaneous multi-slice multi-shell diffusion MRI to assess white matter microstructural changes in chronic military mTBI. Preliminary results showed parameters derived from diffusion MRI biophysical modeling are superior to the parameters derived from diffusion tensor imaging in differentiating tissues with distinct structural and architectural features, and thus has increased ability to identify microstructural changes in mTBI.
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