In this study, we identified robust differences in BOLD-CVR across the brain which were explained, in part, by hemodynamic parameters relating to CBF modulation, and resting metabolic and vascular physiology. These results emphasize that while BOLD-CVR offers promises as a surrogate biomarker for cerebrovascular health, following sport-concussion, multiple hemodynamic parameters can affect its relative measurements. Thus, multi-parametric approaches like the one proposed here should be considered, in order to better understand how head injuries can relate to changes in the vascular reactivity of the brain, post-injury, and avoid naïve interpretation of neuroimaging findings.
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