Abstract #2986

Cellular correlates of multi-parametric magnetic resonance imaging in the human cerebral cortex

Yash Patel^1,2, Mark Drakesmith³, John Evans³, and Tomas Paus^2,4

¹Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ²Bloorview Research Institute, East York, ON, Canada, ³CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴Department of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada

To investigate the neurobiological underpinnings of common parametric MRI maps, including T1, T2 relaxation, myelin water fraction (MWF), magnetization transfer ratio (MTR), and synthetic T1w/T2w ratio, using a virtual histology approach. Simply put, we relate inter-regional profiles of these MR measures to inter-regional profiles of cell- specific gene-expression profiles. We observe a relationship between oligodendrocyte- specific gene-expression with profiles of T2, MWF, synthetic T1w/T2w – interpreted as sensitive to intra-cortical myelination. Lastly, MTR was not correlated with oligodendrocyte specific profile, rather with profiles of dendritic arbour enriched gene sets (CA1 pyramidal, and ependymal cells).

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