Abstract #2913

Amide Proton Transfer-Weighted (APTw) MRI as a Marker for Risk Stratification of Overall Survival in Patients with Lower Grade Gliomas

Shanshan Jiang¹, Qihong Rui², Hao Yu², Tianyu Zou², Zhengyang Zhu³, Fangyao Chen⁴, Hye-Young Heo¹, Peter van Zijl¹, Zhibo Wen², and Jinyuan Zhou¹

¹Johns Hopkins University, Baltimore, MD, United States, ²Zhujiang Hospital,Southern Medical University, guangzhou, MD, United States, ³Whiting School of Engineering, Baltimore, MD, United States, ⁴Department of Epidemiology and Health Statistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China

We explored the possibility of using the APTw signal intensity as a noninvasive imaging marker for stratifying the risk of overall survival (OS) in patients with lower grade gliomas. 108 patients with newly diagnosed grade-II/III gliomas were included. APTw histogram data were recorded. Routine MRI based descriptors, clinical parameters, and OS were collected. According to the multiple Cox regression models, higher APTw value and IDH-wildtype together showed significant predictive power for shorter OS in the cohort of patients with lower grade gliomas. APTw MRI has potential for preoperative MRI evaluation of lower grade gliomas in terms of predicting patient outcomes.

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