Abstract #2869

Isotropic Restricted Diffusion Correlates with Tumor Cellularity in Pediatric and Adult Malignant Brain Tumors

Zezhong Ye¹, Jeffrey D. Viox², Joshua Lin¹, Sam E. Gary³, Jie Zhan⁴, Chunyu Song¹, Ruimeng Yang⁵, Joshua Rubin⁶, Sonika Dahiya⁷, and Sheng-Kwei Song¹

¹Radiology, Washington University School of Medicine, Saint Louis, MO, United States, ²Medicine, University of Missouri – Kansas City, Kansas City, MO, United States, ³Medical Scientist Training Program, The University of Alabama at Birmingham, Birmingham, AL, United States, ⁴Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China, ⁵Radiology, Guangzhou First People’s Hospital, Guangzhou, China, ⁶Pediatrics, Washington University School of Medicine, Saint Louis, MO, United States, ⁷Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, United States

We demonstrated how ADC inconsistently correlates with histologically determined tumor cellularity rendering it an unreliable imaging biomarker of tumor cellularity in pediatric and adult malignant brain tumors. In contrast, modified-diffusion basis spectrum imaging (DBSI)-derived restricted isotropic diffusion fraction correlated with histology-determined cellularity in pediatric and adult malignant brain tumors.

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