Our purpose was to investigate potential correlations amide proton transfer signal intensity (APTSI) with apparent diffusion coefficient, relative cerebral blood volume and pharmacokinetic imaging parameters in high grade glioma (HGG). APTSI showed significant positive correlations with ADC (ρ = 0.582, p < 0.001) and with Ve (ρ = 0.300, p = 0.002), and a significant negative correlation with Kep (ρ = -0.337, p = 0.002). These results suggested that high APTSI in HGG may reflect proteins and peptides in large extracellular space, in addition to those in the intracellular space.
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