Abstract #2856

The study of relationship between amide proton transfer(APT) imaging and IDH mutation status in patients with high-grade gliomas

Yonglu Chen^1,2, Xinfeng Xie¹, Yingjie Mei³, Yuelong Yang¹, Xiaoling Wu¹, Hongjun Liu¹, and Biao Huang¹

¹Department of Radiology, Guangdong General Hospital, Guangdong Academy Of Medical Sicences, Guangzhou, China, ²Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, ³Philips Healthcare, Guangzhou, China

We want to investigate the association of amide proton transfer weighted imaging (APTw) with isocitrate dehydrogenase (IDH) wild-type and IDH mutant of high-grade gliomas.All patients underwent MR scan, including APT san to getting the APT values of the whole tumor. The APT value of the IDH wild type group was significantly higher than that of the IDH mutant group. We conclude that APTw can be used to predict the gene type of IDH in high-grade gliomas before surgery.

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