Abstract #2810

Age-related changes in tissue T1, T2 values of the human brain quantified by 2D PnP-MRF at 7T MRI

Koji Fujimoto¹, Martijn A Cloos², Atsushi Shima³, Dinh Ha Duy Thuy¹, Nobukatsu Sawamoto⁴, Ryosuke Takahashi³, Tadashi Isa^1,5, and Tomohisa Okada¹

¹Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁵Department of Neuroscience, Graduate School of Medicine, Kyoto University, Kyoto, Japan

To investigate age-related changes in T1 and T2 of brain tissues at 7T, healthy volunteers　(N=45, age range 20-81) were scanned using a 1ch-Tx/32ch-Rx coil and a Plug-and-Play MR Fingeprinting (prototype) sequence. Six brain regions (putamen, globus pallidus, caudate head, thalamus, frontal white matter (WM) and frontal gray matter (GM)) were evaluated. Linear and quadratic curve fitting was performed. Significant linear correlation in T2 was found for the putamen and frontal WM and a quadratic correlation was found for the putamen (T2), globus pallidus (T2), thalamus (T1) and frontal WM (T1/T2).

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