Abstract #2782

Diffusion Tensor Imaging of the Superior Thalamic Radiation and Cerebrospinal Fluid Distribution in Idiopathic Normal Pressure Hydrocephalus

Khader M Hasan¹, Kyan Younes², Arash Kamali¹, Zafer Keser², Pejman Rabiei¹, Christine E McGough³, Omar Hasan², Tomas Melicher⁴, Larry A Kramer¹, and Paul E Schulz²

¹Diagnostic and Interventional Imaging, UThealth, McGovern Medical School, Houston, TX, United States, ²Neurology, UThealth, McGovern Medical School, Houston, TX, United States, ³UThealth, McGovern Medical School, Houston, TX, United States, ⁴Psychiatry, UThealth, McGovern Medical School, Houston, TX, United States

Ventricular enlargement in elderly raises a challenging differential diagnosis to physicians. While Alzheimer`s disease is the most common form of dementia, idiopathic Normal Pressure Hydrocephalus (iNPH) constitutes a potentially reversible syndrome. iNPH has a unique pathophysiology pertaining to cerebrospinal fluid dynamics and periventricular white matter. We aimed to determine the effects of iNPH on periventricular white matter bundles and to further characterize its ventricular and sulcal CSF distribution by using diffusion tensor tractography (DTT) and cerebrospinal fluid (CSF) volumetrics on high resolution T1-weighted MRI data.

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