Abstract #2758

Amygdala dysfunction during negative emotional control in Obsessive-Compulsive Disorder: an fMRI study

Hyunsil Cha¹, Sang Won Lee², Kyungeun Jang¹, Eunji Kim¹, Heajeong Choi¹, Jiung Yang¹, Seungho Kim¹, Jinsu Park¹, Moon Jung Hwang³, Huijin Song⁴, Hui joong Lee⁵, Seung Jae Lee², and Yongmin Chang⁶

¹Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, ²Department of Psychiatry, Kyungpook National University Hospital, Daegu, Korea, Republic of, ³Ge Healthcare, Seoul, Korea, Republic of, ⁴Biomedical Engineering Research, Kyungpook National University, Daegu, Korea, Republic of, ⁵Department of Radiology, Kyungpook National University Hospital, Daegu, Korea, Republic of, ⁶Department of Radiology and Molecular Medicine, Kyungpook National University, Daegu, Korea, Republic of

We investigated brain activation in obsessive-compulsive disorder (OCD) patient using thought-action fusion (TAF) task to assess the influence of OCD symptom on amygdala response to the task. Context-dependent psycho-physiological interaction (PPI) analysis of close condition showed decreased amygdala PPI with putamen in patients with OCD compared to healthy controls.

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