Cerebral Venous Blood Volume Estimation Using Velocity-Selective Spin Labeling Prepared Single-Slab Three-Dimensional Turbo Spin Echo Imaging

Venous CBV (CBVv) is of relevance to brain oxygenation level changes during functional activation. To date, MRI techniques for CBVv mapping fall into two categories, based on a 1) quantitative BOLD (qBOLD) model of extravascular signals, and 2) hyperoxic stimulus induced changes in intravascular signal. However, in the former estimation accuracy is impaired due to mutual coupling between CBVv and Yv in the model, while the latter suffers from the complexities in both experiments and estimation involving multiple parameters. Here, we propose velocity-selective spin labeling prepared single-slab 3D TSE imaging for straightforward derivation of CBVv maps in the whole brain. Results from three subjects show plausible values of CBVv estimates in the range of 1.9 - 3.3 % and 1.1 - 2.1 % for gray and white matter, respectively.