Abstract #2721

Comparison of Gradient Echo and Gradient Echo Sampling of Spin Echo Sequence for the Quantification of the Oxygen Extraction Fraction by Combining Quantitative Susceptibility Mapping and Blood Oxygenation Level Dependency

Simon Hubertus¹, Sebastian Thomas¹, Junghun Cho², Shun Zhang^3,4, Yi Wang^2,3, and Lothar R. Schad¹

¹Computer Assisted Clincial Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States, ³Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ⁴Department of Radiology, Tongji Hospital, Wuhan, China

The oxygen extraction fraction (OEF) is a promising biomarker for cerebral tissue vitality. Combining quantitative blood oxygenation level-dependent (qBOLD) modelling and quantitative susceptibility mapping (QSM) from gradient echo (GRE) data revealed promising results but still suffered from biases in white matter and required good parameter initialization. We showed that using an additional gradient echo sampling of spin echo (GESSE) sequence enables OEF reconstruction with higher accuracy, precision and robustness to parameter initialization in simulation. Yet, this increased robustness did still not allow for parameter initialization without prior knowledge of local distributions in vivo, which lead to a non-physiological gray-white matter contrast in the OEF.

This abstract and the presentation materials are available to members only; a login is required.

Join Here