Abstract #2711

Towards Validating Structural Connectivity in the Human Language System: an Intraoperative Cortico-Cortical Stimulation Experiment

Patryk Filipiak¹, Fabien Almairac², Théodore Papadopoulo¹, Denys Fontaine², Lydiane Mondot², Stéphan Chanelet², Maxime Descoteaux³, Rachid Deriche¹, Maureen Clerc¹, and Demian Wassermann^1,4

¹INRIA Sophia Antipolis-Méditerranée, Université Côte d'Azur, Valbonne, France, ²Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, Nice, France, ³Sherbrooke Connectivity Imaging Lab (SCIL), University of Sherbrooke, Sherbrooke, QC, Canada, ⁴INRIA, CEA, Université Paris-Saclay, Paris, France

We validate structural connectivity measures based on diffusion MRI with Electrical Stimulation (ES) of the human brain cortex. For this, we combine white matter fiber tractography with propagation of Cortico-Cortical Evoked Potentials (CCEPs) induced by intrasurgical ES in the language system of brain tumor patients. Our results show high correlation (Pearson's coefficient 0.5-0.9) between delays of CCEPs and pathways connecting stimulation sites with recording electrodes. Our approach outperforms earlier study based on Diffusion Tensor Imaging. This potentially indicates that probabilistic tractography is an effective tool to quantify cortico-cortical communication non-invasively.

This abstract and the presentation materials are available to members only; a login is required.

Join Here