Abstract #2694

Stronger small-worldizition of structural networks in drug-naïve children and adolescents with ADHD：A graph theory analysis

Lu Lu¹, Shi Tang¹, Lianqing Zhang ¹, Xinyu Hu¹, Xuan Bu¹, Hailong Li¹, Xiaoxiao Hu¹, Yingxue Gao¹, Yanlin Wang¹, John Adrian Sweeney^1,2, Qiyong Gong¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, United States

Structural connectomes of patients with ADHD showed a shift toward “stronger small-worldization” which provided a structural basis for higher rates of information transfer in this disorder. These global network alterations, together with increased connectivity within and among DMN and task-positive networks including FPN, DAN and VAN, could lead to disruptions of attention and goal-oriented behavior that are the primary clinical hallmarks of ADHD.

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