Abstract #2643

A Time-Averaged MRI Brain Template for the Infant Rhesus Macaque

Jason Moody¹, Steve Kecskemeti², Douglas Dean III², Jonathan Oler³, Do Tromp³, Andrew Alexander⁴, and Ned Kalin³

¹Department of Medical Physics, University of Wisconsin Madison, Madison, WI, United States, ²Waisman Center, University of Wisconsin Madison, Madison, WI, United States, ³Department of Psychiatry, University of Wisconsin Madison, Madison, WI, United States, ⁴Department of Medical Physics, Department of Psychiatry, Waisman Center, University of Wisconsin Madison, Madison, WI, United States

Anatomical templates are extremely prevalent in human brain imaging research, but comparatively rare in non-human primate MRI studies, particularly for the early-developing brain. Utilizing a custom T1-weighted imaging sequence (MPnRAGE), we have constructed a finely-sampled (0.469 mm isotropic), T1-weighted, time-averaged, population template of the infant rhesus macaque brain, generated from 35 rhesus monkeys, scanned at five different time points throughout their first year of life (including 4 scans within the first 6 months). This time-averaged template of the early-developing rhesus macaque brain provides an invaluable anatomical framework for characterizing and assessing early brain development in non-human primates.

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