Abstract #2582

Analysis of changes in brain structure in patients with Parkinson's disease and their correlation with the Hoehn-Yahr stage using the MPRAGE sequence

Chunyan Zhang¹, Ruichen Zhao¹, Jinxia Zhu², Tobias Kober³, Chen Chen¹, Hong Lu⁴, Hongcan Zhu⁴, Bing Xue⁴, Hong Liang⁴, and Jingliang Cheng¹

¹Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²MR Collaboration, Siemens Healthcare, Ltd., Beijing, China, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

In this study, the volume changes of brain structure in Parkinson's disease (PD) patients were analyzed. We found extensive structural brain changes in PD patients, and most of these changes were correlated with the Hoehn-Yahr stage. The results showed that volume changes in some brain regions may be a potential imaging marker for early diagnosis of PD, and the MPRAGE sequence may be a suitable and quick method to provide a reference for clinicians to diagnose PD.

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