Abstract #2579

Longitudinal Changes in Cerebral Blood Flow Calculated by Arterial Spin Labeling MRI in Parkinson’s Disease

Dilek Betul Arslan¹, Sevim Cengiz¹, Kardelen Eryurek², Ozan Genc¹, Ani Kicik², Emel Erdogdu^2,3, Zeynep Tufekcioglu⁴, Basar Bilgic⁴, Hasmet Hanagasi⁴, Aziz Mufit Ulug¹, Ibrahim Hakan Gurvit⁴, Tamer Demiralp^2,5, and Esin Ozturk-Isik¹

¹Biomedical Engineering Institute, Bogazici University, Istanbul, Turkey, ²Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, ³Institute of Psychology and Cognition Research, University of Bremen, Bremen, Germany, ⁴Department of Neurology, Istanbul University, Istanbul, Turkey, ⁵Department of Physiology, Istanbul University, Istanbul, Turkey

The aim of this study is to monitor perfusion changes over one and a half years in Parkinson’s disease with mild cognitive impairment (PD-MCI). Cerebral blood flow (CBF) maps were created for baseline and follow-up scans by fitting a kinetic curve model for each pixel of arterial spin labeling MR images. The CBF maps were registered to MNI152 brain atlas, and perfusion changes were assessed at 119 distinct brain regions. The CBF of PD-MCI patients decreased at occipital fusiform gyrus, right occipital fusiform gyrus, anterior part of left supramarginal gyrus, and anterior part of right middle temporal gyrus over time.

This abstract and the presentation materials are available to members only; a login is required.

Join Here