The olfactory bulb (OB) is highly affected by Lewy bodies, the hallmark pathology of Parkinson's disease (PD). Hyposmia has been reported to occur in the majority of early-stage PD patients. We investigated whether there is olfactory bulb atrophy in early-stage PD patients. Our data demonstrated significantly reduced olfactory bulb volumes as well as lower psychophysical smell test scores in H&Y stage-1 PD patients compared to healthy controls.
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