Abstract #2567

The influence of draining veins on apparent grey matter volume changes caused by hypercapnia

Julia Huck¹, Christopher J. Steele^2,3, Anna-Thekla Jäger³, Audrey P. Fan⁴, Sophia Grahl³, Christine L. Tardif^5,6, Uta Schneider³, Arno Villringer³, Pierre-Louis Bazin^3,7, and Claudine J. Gauthier^1,8

¹Physics, Concordia University, Montreal, QC, Canada, ²Psychology, Concordia University, Montreal, QC, Canada, ³Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁴Stanford University, Stanford, CA, United States, ⁵Biomedical Engineering, McGill University, Montreal, QC, Canada, ⁶Montreal Neurological Institute, Montreal, QC, Canada, ⁷Social and Behavioural Sciences, University of Amsterdam, Amsterdam, Netherlands, ⁸Montreal Heart Institute, Montreal, QC, Canada

Past studies have shown that T1-weighted measures of grey matter volume (GMV) can be biased by differences in blood volume. Here, we investigate the vascular compartments associated with this bias by quantifying the spatial relationship between t-values for the apparent GMV increase observed during hypercapnia and the location of draining veins. Draining veins were identified using the VENAT atlas. Overall, the results of this analysis demonstrate that while proximity to veins is related to the presence of higher t-values (larger apparent GMV change during hypercapnia), large veins themselves are unlikely to be the main cause of this bias; suggesting that smaller veins or arteries may have a larger role in the observed bias.

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