Abstract #2557

Enhanced perivascular space contrast using T1-T2 fusion and adaptive spatial filtering

Farshid Sepehrband¹, Giuseppe Barisano^1,2,3, Nasim Sheikh-Bahaei³, Meng Law^1,4, and Arthur W Toga¹

¹Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Neuroscience graduate program, University of Southern California, Los Angeles, CA, United States, ³Department of Radiology, University of Southern California, Los Angeles, CA, United States, ⁴Department of Radiology, Alfred Health, Melbourne, Australia

Imaging the perivascular space (PVS), also known as Virchow-Robin space, has shown to be of significant clinical value. Its role in glymphatic system¹ and reported pathological changes of the PVS in neurological disorders^2–10 highlight the need for methodological development specific to this compartment. Here we propose a fusion framework that enhances PVS contrast, allowing robust clinical rating. The Enhanced PVS Contrast (EPC) was achieved by combining T1- and T2-weighted images that were adaptively filtered to remove non-structural high frequency spatial noise.

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