Abstract #2541

Metabolite markers of glutamatergic activity and neuro-inflammation in the superior temporal gyrus in patients with schizophrenia.

Sai Krishna Merugumala¹, M. A. Niznikiewicz², E. Del Re², K. Spencer², H. Liao¹, P. G. Nestor³, R. W. McCarley³, N. Bolo⁴, and A. P. Lin¹

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Boston, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Beth Isreal Deaconess Medical Center, Boston, MA, United States

Many studies have shown that the superior temporal gyrus undergoes many changes in schizophrenia. Magnetic resonance spectroscopy studies of the brain have also shown brain metabolite levels are altered in schizophrenia however the superior temporal gyrus has not been examined in detail. The aim of this study was to compare brain metabolite levels in patients with schizophrenia and controls as well as examine their correlation with electrophysiology measures.

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