Abstract #2505

NOE enhancement for 31P-MRS of skeletal and cardiac muscle at 7T

Chang-Hoon Choi^1,2, Ladislav Valkovic^2,3, William T. Clarke⁴, Albrecht I. Schmid^2,5, N. Jon Shah^1,6,7,8, and Christopher T. Rodgers^2,9

¹Institute of Neuroscience and Medicine-4, Forschungszentrum Juelich, Juelich, Germany, ²Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, ³Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislave, Slovakia, ⁴Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, ⁵High-Field MR Centre, Centre for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ⁶Institute of Neuroscience and Medicine-11, JARA, Forschungszentrum Juelich, Juelich, Germany, ⁷JARA-BRAIN-Translational Medicine, Aachen, Germany, ⁸Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁹The Wolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

Phosphorus MR spectroscopy (³¹P-MRS) is a proven method for probing tissue energetics and membrane metabolism. Nuclear Overhauser effect (NOE) enhancement can considerably improve the quality of ³¹P spectra. This has been demonstrated in the brain and prostate at 7T, but NOE has not yet been applied elsewhere in the human body at 7T. In this study, we evaluated NOE enhancement for ³¹P-MRS in human skeletal muscle and in the heart in vivo at 7T. We observe significant enhancements (e.g. for PCr/γ-ATP: 25%/16% in muscle, 31%/11% in heart), within regulatory SAR limits and without increasing the scan duration.

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