Abstract #2493

Spectroscopic imaging of macromolecule-suppressed J-difference editing of GABA at 3 Tesla

Kimberly Chan^1,2,3 and Peter Barker^2,3

¹Department of Biomedical Engineering, The Johns Hopkins University School, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

In this study, the feasibility of macromolecule-suppressed MR spectroscopic imaging (MRSI) of GABA in the human brain at 3T was investigated. PRESS-localized MRSI was performed for both macromolecule (MM)) suppressed GABA and non-suppressed (GABA+) editing. GABA concentrations and MM fractions were assessed and compared. Data quality metrics (B0 homogeneity, and GABA and water fit errors) were also calculated. A significant linear correlation of GABA+ with GABA concentrations was found. MM-suppressed GABA and GABA+ concentrations agreed with previously reported single-voxel values. Data quality metrics were also similar to those of prior single-voxel acquisitions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here