Abstract #2392

MR spectroscopy to assess decreased tumor choline as a marker of response to choline kinase inhibitors

Claire Louise Kelly¹, Clementine Lesbats¹, Sofya Osharovich ², Arthur Taylor¹, Violaine See³, Edward Jim Delikatny², and Harish Poptani¹

¹Centre for Preclinical Imaging, University of Liverpool, Liverpool, United Kingdom, ²Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Biochemistry, Centre for Cell Imaging, Liverpool, United Kingdom

Tumor volume and single voxel in vivo ¹H MRS were used to assess the effects of the choline kinase inhibitor JAS239 in the F98 rat glioblastoma (GBM) model. Five F344 rats were inoculated with GBM cells and subsequently treated for 5 consecutive days with 4 mg/kg JAS239 or saline. A reduction in total choline (tCho) in tumors treated with JAS239, along with tumor growth arrest was noted in comparison to saline treated rats. JAS239 preferentially inhibited choline metabolism in tumors as no changes were observed in tCho levels from the contralateral brain.

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