Molecular MRI differentiation between thyroid papillary carcinoma and thyroid adenoma without cystic degeneration using endogenous protein-based Amide Proton Transfer  Signals

To identify thyroid papillary carcinoma from thyroid adenoma, we acquired amide proton transfer(APT) value of the both by using the 3T MRI. The differences of APT value of the both were statistically compared by means of nonparametric methods and receiver operating characteristic (ROC) curve analyses were used. The results showed statistical differences among the two nodules, suggesting that APTw imaging can be considered for differentiation of thyroid carcinoma from benign thyroid carcinoma.