Abstract #2358

Non-gaussian IVIM-DWI for HPV-related oropharyngeal cancer patients who received marked dose de-escalation in chemo-radiotherapy: Intra-treatment imaging response evaluation

Ramesh Paudyal¹, Nadeem Riaz², Vaios Hatzoglou³, Nancy Lee², and Amita Shukla-Dave^1,3

¹Medical Physcis, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

This study aims to evaluate treatment response in human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinoma using pre- treatment (TX), intra- TX week 1, 2, 3, and post-TX week 4 quantitative imaging metrics derived from non-Gaussian IVIM DWI. ADC and D showed a significant increase between pre- and post-TX week 4 in complete response (CR) group, who were treated with dose de-escalation to 30Gy chemo-radiation therapy.

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