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Abstract #2356

Optimized tumor volumes by dynamic contrast enhanced MR imaging for assessing response to neoadjuvant chemotherapy in triple negative breast cancer

Benjamin Charles Musall1, Beatriz E Adrada2, Abeer H Abdelhafez2, Hagar S Mahmoud2, Ken-Pin Hwang1, Jong Bum Son1, Lumarie Santiago2, Gary J Whitman2, Huong Le-Petross2, Tanya W Moseley2, Rosalind P Candelaria2, Bora Lim3, Senthil Damodaran3, Jennifer K Litton3, Stacy L Moulder3, Wei T Yang2, Jingfei Ma1, Mark D Pagel4, and Gaiane M Rauch2

1Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, 2Diagnostic Radiology, MD Anderson Cancer Center, Houston, TX, United States, 3Breast Medical Oncology, MD Anderson Cancer Center, Houston, TX, United States, 4Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, United States

We evaluated several methods of measuring tumor volumes on DCE MRI for assessment of treatment response in triple negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NAC), including functional tumor volume (FTV), enhanced tumor volume(ETV), and clinical tumor volume (CTV). We compared different parameters for measurement of functional tumor volume at baseline as well as its changes during therapy, and established optimal parameters for FTV measurements. We found that optimized FTV and ETV have potential to serve as an imaging biomarker for evaluation of NAC treatment response in TNBC patients

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