Abstract #2352

Evaluating the effectiveness of preload in mitigating the leakage effect of dynamic contrast susceptibility MRI

Xin Li¹, Seymur Gahramanov², Ramon F Barajas³, and Edward A Neuwelt⁴

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Department of Neurosurgery, University of New Mexico, Albuquerque, NM, United States, ³Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States, ⁴Neurology, Oregon Health & Science University, Portland, OR, United States

Dynamic Susceptibility Contrast (DSC) Magnetic Resonance Imaging (MRI) with low molecular weight Gadolinium based contrast agent (GBCA) is often confounded by GBCA’s leakage into intersitium space. Thus, pre-DSC injection of GBCA (preload) is often used to mitigate the underestimation of relative cerebral blood volume (rCBV) due to the leakage of GBCA. Here, we present results to demonstrate that preload is generally effective. However, small dose effect could still be expected in the process.

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