Tumor burden, tumor proliferation, and tumor hypoxia, all of which vary in space and time, are evidence-based contributors of radiotherapy failure. In addition, it has been demonstrated that gene expression can influence radiosensitivity. We demonstrate here the initial feasibility of a framework to incorporate genomic and radiographic information to derive patient-specific, voxelwise radiation dose prescription maps for use in a biologically adaptive MR-guided radiotherapy (BAMRgRT) strategy.
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