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Abstract #2315

Quantification of Cerebral Blood Flow using arterial spin labeling in glioblastoma multiforme; challenges of calibration in the presence of oedema.

Paula L Croal1,2, Flora Kennedy-McConnell1,2, Benjamin Harris3,4, Ruichong Ma4, Stasya M Ng3, Puneet Plaha4,5, Simon Lord3,4, Nicola R Sibson6, and Michael A Chappell1,2

1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2Wellcome Centre for Integrative Neuroscience, University of Oxford, Oxford, United Kingdom, 3Department of Oncology, University of Oxford, Oxford, United Kingdom, 4Oxford University Hospitals NHS Trust, Oxford, United Kingdom, 5Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom, 6Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom

Arterial spin labeling (ASL) offers a non-invasive and repeatable method for quantifying CBF, a promising biomarker in cancer imaging. However, the consensus for voxelwise calibration may not be appropriate for application in tumours. We hypothesise that voxelwise calibration in the presence of oedema will decrease sensitivity to alterations in CBF, and test this by measuring CBF with pseudocontinurous ASL in seven patients with glioblastoma multiforme, comparing the impact of voxelwise, white matter, and CSF calibration on tumour CBF. Calibration choice significantly affects absolute CBF; with a loss of CBF contrast in tumours when using voxelwise calibration, which may have clinical implication.

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