Abstract #2301

Choline kinase-α downregulation decreases prostate cancer associated fibroblast viability

Jesus Pacheco-Torres¹, Flonne Wildes¹, Tariq Shah¹, Balaji Krishnamachary ¹, and Zaver M Bhujwalla^1,2,3

¹Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science. The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center. The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cancer associated fibroblasts (CAFs) significantly influence the proliferation, invasion, and metastasis of cancer cells. CAFs are detected in most tumors and provide a ubiquitous target that is being actively investigated in cancer treatment. In prostate cancer, fibroblasts have been shown to induce growth, confer castration-resistance, and increase metastatic potential. Choline kinase (Chk)-α downregulation has been previously shown to significantly decrease cancer cell viability but its effect on CAFs has not been investigated before. Here we found, for the first time, a significant decrease of prostate cancer fibroblast (PCAF) viability with Chk-α downregulation.

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