1H-MRS is extensively used to measure the hepatic lipid content. Conventionally, the water resonance is used as an internal reference, thereby assuming a constant T2 decay of water across individuals to estimate absolute hepatic lipid content. However, the T2 values reported in literature for 3T vary widely, which might be due to different subject populations and/or other methodological discrepancies. The purpose of this study was to measure T2 of water in a group of subjects with a wide range of hepatic lipid content and to evaluate whether there is a dependence of water T2 relaxation times and hepatic lipid fraction.
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