In various pathologies, changes in cerebral metabolite concentrations are accompanied by variations in the broader underlying lipid/macromolecular components. This introduces important biases in quantification at short echo times which, if unaddressed, undermine experiments which compare subjects with different injury severities.
Here we demonstrate the benefits of employing a simple two-point saturation recovery MRS experiment to reduce this bias introduced by pathology – in this case, taking the example of neonatal encephalopathy. This ability to accurately quantify spectra at all pathology severities is crucial for clinical trials, where biases would otherwise suppress sensitivity to important treatment effects.
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