Abstract #2246

An Analysis of 1H Metabolite Residuals in an Acquired Macromolecule Spectrum

David McAllindon^1,2, Chris Bowen^2,3,4, Denise Bernier^1,5, and Philip G Tibbo^1,5

¹Psychiatry, Dalhousie University, Halifax, NS, Canada, ²Biomedical Translational Imaging Center, IWK Health Center, Halifax, NS, Canada, ³Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Canada, ⁴Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, ⁵Nova Scotia Early Psychosis Program, Nova Scotia Health Authority, Halifax, NS, Canada

Macromolecules underly the metabolites in short-TE ¹H magnetic resonance spectroscopy and must be accounted for in a quantitative analysis. One method is to acquire a metabolite-nulled spectrum and use it to account for macromolecules in fitting; however, since metabolites have a range of T1, metabolite-nulling is incomplete and leaves residuals. We introduce a new metabolite cleaning method with 2 metabolite-nulling schemes, single inversion and double inversion, and use it to examine the estimated metabolite residuals, finding that even with double-inversion nulling, there are substantial metabolite residuals of 10-35% in the macromolecule spectrum.

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