Abstract #2241

A pilot study on the GABA+ level in midbrain of healthy volunteers using MEGA-PRESS technique

Yulu Song¹, Tao Gong¹, Fei Gao¹, Richard A.E. Edden², Weibo Chen³, and Guangbin Wang¹

¹Shandong Medical Imaging Research Institute, Jinan, China, ²The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Philips Healthcare, Shanghai, China

Gamma-aminobutyric acid (GABA) in midbrain is insignificant to be measured. To determine the GABA+ level, we employed Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) by a small region of interest (ROI)(1.0 × 2.5 × 3.0 cm), which is a new technique that could precisely measure the level of the inhibitory neurotransmitter. The distribution is 2.47 ±0.66 (χ±SD)，and it is prove that there was no correlation of GABA+ level with age in healthy volunteers.

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