Abstract #2237

LCModel comparison of MEGA-PRESS and HERMES for GABA (and GSH) editing at 3T

James B. Murdoch¹, Ferdinand Schweser^2,3, Muhammad G. Saleh^4,5, and Richard A.E. Edden^4,5

¹Canon Medical Research USA, Mayfield Village, OH, United States, ²Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁴Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

HERMES is a new Hadamard-based editing sequence that allows for the simultaneous acquisition of overlapping metabolite signals – most notably GABA and glutathione (GSH) at TE 80. As such, HERMES is an alternative to conventional GABA measurement using TE 68 MEGA-PRESS, providing GSH information “for free.” In this work, we showed in a series of matched-voxel spectra that %SD values from LCModel were on average only slightly larger for HERMES than for MEGA-PRESS, suggesting that only a small price is paid in terms of GABA sensitivity.

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