Abstract #2217

A swine model of selective coronary stenosis using transcatheter delivery of a 3D printed implant for MR imaging: Feasibility and Efficacy

Caroline M. Colbert^1,2, Jiaxin Shao², Jesse W. Currier³, Olujimi A. Ajijola⁴, Rohan Dharmakumar⁵, Sandra M. Duarte-Vogel^2,6, Peng Hu^1,2, and Kim-Lien Nguyen^1,2,3

¹Physics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ²Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ³Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, ⁴UCLA Cardiac Arrhythmia Center and Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁵Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, and Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁶Department of Laboratory Animal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

This study aims to investigate the feasibility and efficacy of a closed-chest method for coronary stenosis creation in swine models of ischemic heart disease (IHD). We successfully deployed high-resolution 3D printed intracoronary implants in three healthy swine subjects using a transcatheter angioplasty delivery approach. All subjects underwent angiography and MR cine imaging for assessment of ventricular regional wall motion. At post-mortem dissection, we successfully retrieved the implants. These results support early feasibility and efficacy of our proposed approach for applications including stress testing, infarct creation, and evaluation of diagnostic techniques or therapeutics in swine models of IHD.

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