Abstract #2210

Optimization of Steady-Pulsed Arterial Spin Labeling for Myocardial Perfusion Imaging

Ahsan Javed¹, Nam Gyun Lee², Hung Phi Do³, Nilesh Ghugre⁴, Graham Wright⁴, Eric Wong⁵, and Krishna S Nayak^1,2

¹Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ²Biomedical Engineering, University of Southen California, Los Angeles, CA, United States, ³Department of Clinical Collaborations, Canon Medical Systems USA, Tustin, CA, United States, ⁴Sunny Brook Research Institute, University of Toronto, Toronto, ON, Canada, ⁵Electrical Engineering, University of California Sandiego, Sandiego, CA, United States

Arterial spin labeling (ASL) is an attractive non-contrast option for myocardial perfusion imaging. Steady pulsed labeling has been shown to provide the highest signal efficiency in-vivo. In this work, we determine the flip-angle and imaging interval that provide maximum signal efficiency and temporal SNR using Bloch simulation and experiments in healthy swine. We demonstrate that an imaging FA of 40-50ºand imaging interval of 1-RR is optimal.

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