Abstract #2203

Comparison of room temperature, refrigerator and cryogenic storage for preservation of blood clot R2* and quantitative susceptibility values in vitro at 3T

Spencer D Christiansen^1,2, Junmin Liu¹, Joy Dunmore-Buyze¹, Mike B Boffa³, and Maria Drangova^1,2

¹Imaging Research Laboratories, Robarts Research Institute, Western University, London, ON, Canada, ²Dept. of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ³Dept. of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada

Mechanical thrombectomy therapy allows valuable stroke thrombus MR imaging studies to be completed without patient burden, but the effects of delay between retrieval and imaging on MR characteristics need to be considered. We tested the ability of room temperature, refrigerator and cryogenic storage to preserve blood clot R₂^* and quantitative susceptibility (QS) values up to 48 hours in vitro. Room temperature storage provided adequate preservation up to 24 hours while refrigerator storage significantly decreased R₂^* and QS; cryogenic storage led to non-significant decreases in R₂^* and QS and shows promise for complete, long-term preservation if cell lysis can be mitigated.

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