Effect of nicotine administration on myocardial perfusion under adenosine stress: A dynamic investigation using cine-ASL in mice.

We have monitored myocardial perfusion (MBF) dynamically under pharmacologically-induced stress in mice using a time-optimized cine-ASL MRI approach with about 2.5min temporal resolution. One main advantage of the repeatable cine-ASL in this context is to monitor MBF during successive stress episodes in the same animal allowing for internal control. In this study we clearly demonstrated that single bolus nicotine administration (1mg·kg^-1) significantly reduced perfusion by 35% under adenosine stress (tail vein continuous infusion, 90µg·kg^-1·min^-1) in healthy mice.