Aim of the project is the computational modeling of contrast agent dispersion in coronary arteries down to pre-arteriolar level during contrast-enhanced MRI myocardial perfusion measurements. From a high resolution imaging cryomicrotome dataset a vascular 3D model of the left main coronary artery is extracted and furnished with a computational grid. Using an advanced boundary condition, Navier-Stokes equations for blood flow and the advection-diffusion equation for CA transport are solved to obtain CA bolus dispersion values on this model of unprecedented detail, and to analyze myocardial blood flow quantification errors. The analysis of the obtained results shows strong variability on the cm-scale.
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