Abstract #2179

Parametric measurements of acute myocardial infarction in a large preclinical model

Jakob Lindhardt¹, Esben Søvsø Szocska Hansen¹, Rasmus Stilling Tougaard^1,2, Nikolaj Bøgh³, Rolf Schulte⁴, and Christoffer Laustsen¹

¹MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 8200 Aarhus N, Denmark, ²2Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark, Aarhus N, Denmark, ³The Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Denmark, Aarhus N, Denmark, ⁴GE Healthcare, Munich, Germany, Munich, Germany

Hyperpolarized [1-13C]pyruvate was used to evaluate metabolic and perfusion changes in myocardial infarction in the critical acute reperfusion phase. Regional changes was observed by mapping of metabolic ratios of lactate, alanine and bicarbonate. Metabolic exchange rates from hyperpolarized fumarate was calculated using Michael-Menten kinetics. Hyperpolarized measures were compared with standard perfusion MRI and tissue staining evaluating infarction and salvage. The results of this study, draws use of hyperpolarized [1-13C]pyruvate closer to evaluation of myocardial infarction in a human study.

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