Quantification of 2D and 3D myocardial strain at cine frame-rates has been previously demonstrated with echo-planar and spiral sequence versions of Displacement Encoding with Stimulated Echoes (DENSE). However, these non-conventional acquisition methods, with their sensitivities to off-resonance, has hindered their integration into mainstream cardiac MRI application. Here we present a more conventional, but highly accelerated, balanced SSFP (bSSFP) version of Cardiac Cine 3D-DENSE for application to human subjects. In vivo human scans at 3T demonstrated good agreement of myocardial radial (Err), circumferential (Ecc) and longitudinal Ell) strain values between bSSFP 3D-DENSE to those reported in previous literature.
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